伯信生物建立了熒光原位雜交探針（FISH Probe）制備平臺，承接熒光原位雜交試劑盒定制業(yè)務，可根據(jù)客戶需求進行個性化定制。
該試劑盒主要用于檢測樣本中目的基因的表達量與表達部位，可應用于組織切片（石蠟切片/冰凍切片）、細胞爬片與染色體片等的檢測。
伯信生物采用從研究物種自體獲取特異性探針并進行化學共價方式與熒光素連接。
自體熒光探針具有明顯的優(yōu)越性：靈敏度高，光穩(wěn)定性好，熒光壽命長；最大的優(yōu)勢就是自體探針可以有效的降低自體的非特異熒光干擾，達到更加高效特異的基因檢測信號。
通過對比將會產(chǎn)生極大的技術(shù)效應，獲取客戶的認可并替代傳統(tǒng)的探針檢測，滿足國內(nèi)外科研工作者對高質(zhì)量的熒光探針原位雜交試劑盒的實驗需求。
伯信生物熒光原位雜交試劑盒，自上市以來深受廣大科研用戶的歡迎和肯定，為中國科學院、中山大學醫(yī)學院及附屬醫(yī)院、南方醫(yī)科大學醫(yī)學院及附屬醫(yī)院、香港大學、北京大學醫(yī)學部及附屬醫(yī)院、東南大學醫(yī)學院、江西農(nóng)業(yè)大學、華中科技大學、同濟醫(yī)學院等國內(nèi)一流科研院所、醫(yī)療機構(gòu)及跨國生物企業(yè)等近千家用戶提供了優(yōu)質(zhì)的服務。
同時經(jīng)過多年的積累，2011年建立了分子探針研發(fā)中心，伯信生物擁有強大的熒光原位雜交技術(shù)團隊，為客戶在試劑盒使用中遇到的各種問題給予技術(shù)支持和解答。
目前公司擁有庫存現(xiàn)貨試劑盒種類已達近萬種：其中mRNA 1245種；microRNA 3171種，種屬涵蓋人、大小鼠、兔、豬、雞、細菌、昆蟲類等等，以及其他常規(guī)染色體探針及種屬特異性探針等。
實驗原理：
熒光原位雜交（Fluorescent in situ hybridization, FISH）是根據(jù)待測核酸序列設(shè)計特異性的熒光素標記寡聚核苷酸探針，再經(jīng)過共變性-退火-復性，使探針與靶DNA/RNA按照堿基互補配對原則形成雜交體，最后利用熒光顯微鏡直接檢測熒光信號，從而對組織、細胞中的待測核酸進行定性、半定量或相對定位分析的一種原位雜交技術(shù)。
技術(shù)流程：
結(jié)果實例：
mRNA FISH
lncRNA FISH
circRNA FISH
DNA FISH
產(chǎn)品優(yōu)勢：
1. 探針制備采用直接標記法，省去了信號放大系統(tǒng)。
2. 熒光信號強，結(jié)果判定直觀可靠。
3. 根據(jù)客戶需求定制個性化探針。
4. 特異性強，靈敏度高，背景低。
5. 探針性能穩(wěn)定，低溫保存一年以上。
6. 同時示蹤核酸和蛋白的定位情況。
7. 操作簡單，安全、快速，重復性好。
詳見產(chǎn)品說明書：Bes1001 RNA-FISH（短鏈）
詳見產(chǎn)品說明書：Bes1002 RNA-FISH（長鏈）
詳見產(chǎn)品說明書：Bes1011 DNA-FISH
文章案例
【2025年】
Article：Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts.（DNA-FISH）
Periodicals：Nature Genetics
IF：29.000
Article：Lung metastasis and recurrence is mitigated by CAR macrophages, in-situ-generated from mRNA delivered by small extracellular vesicles.（DNA-FISH）
Periodicals：Nature Communications
IF：15.700
Article：Streamlined metal-based hydrogel facilitates stem cell differentiation, extracellular matrix homeostasis and cartilage repair in male rats.
Periodicals：Nature Communications
IF：15.700
Article： Statin therapy associated Lactobacillus intestinalis attenuates pancreatic fibrosis through remodeling intestinal homeostasis. NPJ Biofilms Microbiomes.
Periodicals：NPJ Biofilms and Microbiomes
IF：7.800
Article：TEC-mediated tRF-31R9J regulates histone lactylation and acetylation by HDAC1 to suppress hepatocyte ferroptosis and improve non-alcoholic steatohepatitis.
Periodicals：Clinical Epigenetics
IF：4.800
Article： Erianin ameliorates morphine tolerance and glioma progression through the JAK2-STAT3 pathway.
Periodicals：Translational Oncology
IF：4.100
Article：Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1.
Periodicals：Immunobiology
IF：2.500
【2024年】
Article：LncRNA-Mediated TPI1 and PKM2 Promote Self-Renewal and Chemoresistance in GBM.
Periodicals：Advanced science (Weinheim, Baden-Wurttemberg, Germany)
IF：14.300
Article：EIF4A3 modulated circ_000999 promotes epithelial-mesenchymal transition in cadmium-induced malignant transformation through the miR-205-5p/ZEB1 axis.
Periodicals：Environment International
IF：10.300
Article：Periodic changes of cyclin D1 mRNA stability are regulated by PC4 modifications in the cell cycle.
Periodicals：The Journal of Cell Biology
IF：7.400
Article：MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway.
Periodicals：iScience
IF：7.100
Article：circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer.
Periodicals：Molecular Therapy. Oncology
IF：5.299
Article：Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes.
Periodicals：Annals of Medicine
IF：4.900
Article：Sws2 Gene Positively Regulates Melanin Production in Plectropomus leopardus Skin via Direct Regulation of the Synthesis of Retinoic Acid.
Periodicals：International Journal of Molecular Sciences
IF：4.900
Article： MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway.
Periodicals：iScience
IF：4.600
Article：The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion.
Periodicals：Cellular Signalling
IF：4.400
Article： LncRNA HOTTIP promotes LPS-induced lung epithelial cell injury by recruiting DNMT1 to epigenetically regulate SP-C.
Periodicals：Journal of cell communication and signaling
IF：4.100
Article：Long non?coding RNA DANCR aggravates breast cancer through the miR?34c/E2F1 feedback loop.
Periodicals：Molecular medicine reports
IF：3.400
Article：lncRNA H19 facilitates vascular neointima formation by targeting miR-125a-3p/FLT1 axis.
Periodicals：Acta biochimica et biophysica Sinica
IF：3.300
Article：LncIRF1 promotes chicken resistance to ALV-J infection.
Periodicals：3 Biotech
IF：2.600
【2023年】
Article：circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-β signalling pathway-mediated activation of MMPs in pancreatic cancer
Periodicals：Molecular Cancer
IF：37.299
Article：Augmenting L3MBTL2-induced condensates suppresses tumor growth in osteosarcoma.
Periodicals：Science Advances
IF：13.600
Article：CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg efect
Periodicals：Journal of Experimental &Clinical Cancer Research
IF：12.658
Article：N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.
Periodicals：Translational Neurodegeneration
IF：12.600
Article：Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment.
Periodicals：Journal of experimental & clinical cancer research : CR
IF：11.300
Article：MicroRNA miR-1275 coordinately regulates AEA/LPA signals via targeting FAAH in lipid metabolism reprogramming of gastric cancer
Periodicals：Cell Death and Disease
IF：9.697
Article：Interference of a mammalian circRNA regulates lipid metabolism reprogramming by targeting miR-24-3p/Igf2/PI3K-AKT-mTOR and Igf2bp2/Ucp1 axis.
Periodicals：Cellular and molecular life sciences
IF：6.200
Article： CircZCCHC2 (hsa_circ_0000854) promotes hepatocellular carcinoma progression through modulating miR-936/BTBD7 axis and activating Rho/ROCK2 pathway.
Periodicals：Non-coding RNA research
IF：5.900
Article：Marsdenia tenacissima extract prevents the malignant progression of glioma through upregulating lncRNA MEG3 and SFRP1-dependent inhibition of Wnt/β-catenin pathway
Periodicals：CNS Neuroscience & Therapeutics
IF：5.500
Article：Circular RNA hsa_circ_0005218 promotes the early recurrence of hepatocellular carcinoma by targeting the miR-31-5p/CDK1 pathway
Periodicals：Heliyon
IF：3.776
Article：SLERT, as a novel biomarker, orchestrates endometrial cancer metastasis via regulation of BDNF/TRKB signaling
Periodicals：World Journal of Surgical Oncology
IF：3.253
Article：Screening and Bioinformatics Analyses of Key miRNAs Associated with Toll-like Receptor Activation in Gastric Cancer Cells
Periodicals：Medicina
IF：2.948
【2022年】
Article：TLR4 regulates RORγt+ regulatory T-cell responses and susceptibility to colon infammation through interaction with Akkermansia muciniphila
Periodicals：Microbiome
IF：16.836
Article：Role of lncSLCO1C1 in gastric cancer progression and resistance to oxaliplatin therapy
Periodicals：Clinical and Translational Medicine
IF：11.492
Article：circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3
Periodicals：Biomarker Research
IF：8.633
Article：Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism
Periodicals：Cell Death & Disease
IF：8.469
Article：SIX5-activated LINC01468 promotes lung adenocarcinoma progression by recruiting SERBP1 to regulate SERPINE1 mRNA stability and recruiting USP5 to facilitate PAI1 protein deubiquitylation
Periodicals：Cell Death & Disease
IF：8.469
Article：Bone marrow mesenchymal stem cells inhibit hepatic fbrosis via the AABR07028795.2/rno-miR-667-5p axis
Periodicals：Stem Cell Research & Therapy
IF：8.08
Article：Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA
Periodicals：Molecular Therapy: Oncolytics
IF：7.2
Article：Circular RNA hsa_circ_0083756 promotes intervertebral disc degeneration by sponging miR-558 and regulating TREM1 expression
Periodicals：Cell Proliferation
IF：6.83
Article：OLMALINC/OCT4/BMP2 axis enhances osteogenic-like phenotype of renal interstitial fbroblasts to participate in Randall’s plaque formation
Periodicals：Molecular Medicine
IF：6.382
Article：circDNMT1 Promotes Malignant Progression of Gastric Cancer Through Targeting miR-576-3p/Hypoxia Inducible Factor-1 Alpha Axis
Periodicals：Frontiers in Oncology
IF：6.243
Article：Long noncoding RNA CASC7 is a novel regulator of glycolysis in oesophageal cancer via a miR-143-3p-mediated HK2 signalling pathway
Periodicals：Cell Death Discovery
IF：5.24
Article：Long non-coding RNA lncC11orf54-1 modulates neuroinfammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection
Periodicals：Molecular Brain
IF：4.04
Article：MiR-122-5p promotes peritoneal fibrosis in a rat model of peritoneal dialysis by targeting Smad5 to activate Wnt/β-catenin pathway
Periodicals：Renal Failure
IF：2.6
【2021年】
Article：ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Periodicals：nature communications
IF：12.298
Article：Long noncoding RNA IL6-AS1 is highly expressed in chronic obstructive pulmonary disease and is associated with interleukin 6 by targeting miR-149-5p and early B-cell factor 1
Periodicals：Clinical and translational medicine
IF：11.493
Article：CircRNA Chordc1 protects mice from abdominal aortic aneurysm by contributing to the phenotype and growth of vascular smooth muscle cells
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.886
Article：Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice
Periodicals：Theranostics
IF：8.698
Article：circATP2B1 Promotes Aerobic Glycolysis in Gastric Cancer Cells Through Regulation of the miR-326 Gene Cluster
Periodicals：Frontiers in Oncology
IF：7.561
Article：Global identification of full‐length cassava lncRNAs unveils the role of cold‐responsive intergenic lncRNA 1 in cold stress response
Periodicals：Plant, Cell & Environment
IF：7.2
Article：Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis
Periodicals：Frontiers in Cell and Developmental Biology
IF：6.68
Article：Identification of low-dose radiation-induced exosomal circMETRN and miR-4709-3p/GRB14/PDGFRα pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance
Periodicals：International Journal of Biological Sciences
IF：6.582
Article：LncRNA Nqo1-AS1 Attenuates Cigarette Smoke-Induced Oxidative Stress by Upregulating its Natural Antisense Transcript Nqo1
Periodicals：Frontiers in Pharmacology
IF：5.811
Article：Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction
Periodicals：Aging
IF：5.682
Article：Paeonol inhibits the progression of intracerebral haemorrhage by mediating the HOTAIR/UPF1/ACSL4 axis
Periodicals：ASN Neuro
IF：4.146
Article：Tumor-derived exosomal circRNA051239 promotes proliferation and migration of epithelial ovarian cancer
Periodicals：Am J Transl Res
IF：3.377
Article：Identification and Functional Prediction of Long Non-Coding RNAs in Dilated Cardiomyopathy by Bioinformatics Analysis
Periodicals：Frontiers in Genetics
IF：3.256
Article：Role of long intergenic non-protein coding RNA 01857 in hepatocellular carcinoma malignancy via the regulation of the microRNA-197-3p/anterior GRadient 2 axis
Periodicals：PLOS ONE
IF：3.24
Article：Long non?coding RNA SNHG8 promotes autophagy as a ceRNA to upregulate ATG7 by sponging microRNA?588 in colorectal cancer
Periodicals：Oncology Letters
IF：2.967
Article：MicroRNA-488-3p Regulates Neuronal Cell Death in Cerebral Ischemic Stroke Through Vacuolar Protein Sorting 4B (VPS4B)
Periodicals：Neuropsychiatric Disease and Treatment
IF：2.57
Article：lncRNA RP11?531A24.3 inhibits the migration and proliferation of vascular smooth muscle cells by downregulating ANXA2 expression
Periodicals：Experimental and Therapeutic Medicine
IF：2.447
Article：Long non?coding RNA SNHG8 promotes autophagy as a ceRNA to upregulate ATG7 by sponging microRNA?588 in colorectal cancer
Periodicals：Oncology Letters
IF：2.311
【2020年】
Article：SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：11.161
Article：MicroRNA-3613-5p Promotes Lung Adenocarcinoma Cell Proliferation through a RELA and AKT/MAPK Positive Feedback Loop
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.889
Article：circRNA Hipk3 Induces Cardiac Regeneration after Myocardial Infarction in Mice by Binding to Notch1 and miR-133a
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.889
Article：miR-210-5p promotes epithelial–mesenchymal transition by inhibiting PIK3R5 thereby activating oncogenic autophagy in osteosarcoma cells
Periodicals：Cell Death and Disease
IF：8.469
Article：Long non-coding RNA LRRC75A-AS1 facilitates triple negative breast cancer cell proliferation and invasion via functioning as a ceRNA to modulate
BAALC
Periodicals：Cell Death and Disease
IF：8.469
Article：LncSSBP1 Functions as a Negative Regulator of IL-6 Through Interaction With hnRNPK in Bronchial Epithelial Cells Infected With Talaromyces marneffei
Periodicals：Frontiers in Immunology
IF：7.561
Article：RBFOX1 Regulates the Permeability of the Blood-Tumor Barrier via the LINC00673/MAFF Pathway
Periodicals：Molecular Therapy: Oncolytics
IF：7.2
Article：Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression
Periodicals：Journal of Experimental & Clinical Cancer Research
IF：7.038
Article：circ_2858 Helps Blood-Brain Barrier Disruption by Increasing VEGFA via Sponging miR-93-5p during Escherichia coli Meningitis
Periodicals： Molecular Therapy: Nucleic Acids
IF：7.032
Article：LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca2+-FAK signal pathway
Periodicals：Cell Death & Disease
IF：6.28
Article：SOX9-activated FARSA-AS1 predetermines cell growth, stemness, and metastasis in colorectal cancer through upregulating FARSA and SOX9
Periodicals：Cell Death & Disease
IF：6.28
Article：Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis
Periodicals：Aging
IF：5.682
Article：Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways
Periodicals：Aging
IF：4.909
Article：Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression
Periodicals：OncoTargets and Therapy
IF：4.174
Article：LncRNA RP11?86H7.1 promotes airway infammation induced byTRAPM2.5 by acting as a ceRNA of miRNA?9?5p to regulate NFKB1 in HBECS
Periodicals：Scientific Reports
IF：4.149
Article：LncRNA FLVCR1-AS1 promotes proliferation, migration and activates Wnt/β-catenin pathway through miR-381-3p/CTNNB1 axis in breast cancer
Periodicals：Cancer Cell International
IF：3.991
Article：NONO promotes hepatocellular carcinoma progression by enhancing fatty acids biosynthesis through interacting with ACLY mRNA
Periodicals：Cancer Cell International
IF：3.991
Article：Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway
Periodicals：Cancer Medicine
IF：3.491
Article：Circular RNA 0001073 Attenuates Malignant Biological Behaviours in Breast Cancer Cell and Is Delivered by Nanoparticles to Inhibit Mice Tumour Growth
Periodicals：OncoTargets and Therapy
IF：3.259
Article：Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis
Periodicals：BMC Pulmonary Medicine
IF：2.87
【2019年】
Article：Platelet-derived miR-223 promotes a phenotypic switch in arterial injury repair
Periodicals：The Journal of Clinical Investigation
IF：14.807
Article：Extracellular Vesicles from Albumin-Induced Tubular Epithelial Cells Promote the M1 Macrophage Phenotype by Targeting Klotho
Periodicals：Molecular Therapy
IF：11.455
Article：circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.889
Article：Long noncoding RNA GAS5 induces abdominal aortic aneurysm formation by promoting smooth muscle apoptosis
Periodicals：Theranostics
IF：8.698
Article：Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis
Periodicals：Cell Death and Disease
IF：8.469
Article：Overexpression of long noncoding RNA LINC01419 in esophageal squamous cell carcinoma and its relation to the sensitivity to 5-fluorouracil by mediating GSTP1 methylation
Periodicals：Therapeutic Advances in Medical Oncology
IF：8.168
Article：Exosomal transfer of miR-1238 contributes to temozolomide-resistance in glioblastoma
Periodicals：EBioMedicine
IF：8.142
Article：MicroRNA-206 attenuates glioma cell proliferation, migration, and invasion by blocking the WNT/β-catenin pathway via direct targeting of Frizzled 7 mRNA
Periodicals：American Journal of Translational Research
IF：6.166
Article：MicroRNA-940 inhibits glioma cells proliferation and cell cycle progression by targeting CKS1
Periodicals：American Journal of Translational Research
IF：6.166
Article：CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression
Periodicals：Aging
IF：5.682
Article：Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway
Periodicals：Frontiers in Oncology
IF：4.848
Article：Circular RNAs in human and vertebrate neural retinas
Periodicals：RNA Biology
IF：4.822
Article：Long non-coding RNA F11-AS1 inhibits HBV-related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA-211-5p
Periodicals：Journal of Cellular and Molecular Medicine
IF：4.438
Article：Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease
Periodicals：Neuroscience Bulletin
IF：4.326
Article：Mechanism of aberrant long non-coding RNA expression in an adriamycin-resistant liver cancer cell strain
Periodicals：Digestive and Liver Disease
IF：4.088
Article：Long noncoding RNA SNHG6 functions as a competing endogenous RNA by sponging miR-181a-5p to regulate E2F5 expression in colorectal cancer
Periodicals：Cancer Management and Research
IF：3.989
Article：Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease
Periodicals：Neuroscience Bulletin
IF：3.903
Article：High-throughput sequencing reveals circular RNA hsa circ 0000592 as a novel player in the carcinogenesis of gastric carcinoma
Periodicals：Bioscience Reports
IF：3.411
【2018年】
Article：Multistage Delivery Nanoparticle Facilitates Efficient CRISPR/dCas9 Activation and Tumor Growth Suppression In Vivo
Periodicals：Advanced Science
IF：15.804
Article：circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.889
Article：FEZF1-AS1/miR-107/ZNF312B axis facilitates progression and Warburg effect in pancreatic ductal adenocarcinoma
Periodicals：Cell Death and Disease
IF：8.469
Article：TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway
Periodicals：Journal of Neuroinflammation
IF：5.791
Article：MiR-422a regulates cellular metabolism and malignancy by targeting pyruvate dehydrogenase kinase 2 in gastric cancer
Periodicals：Cell Death & Disease
IF：5.638
Article：TSG-6 attenuates inflammation-induced brain injury via modulation of microglial polarization in SAH rats through the SOCS3/STAT3 pathway
Periodicals：Journal of Neuroinflammation
IF：5.193
Article：Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 promotes lung adenocarcinoma by directly interacting with specificity protein 1
Periodicals：Cancer Science
IF：4.967
Article：MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma
Periodicals：Journal of Neuro-Oncology
IF：4.129
【2017年】
Article：LncRNA-SARCC suppresses renal cell carcinoma(RCC) progression via altering the androgen receptor(AR)/miRNA-143-3p signals
Periodicals：Cell Death and Differentiation
IF：15.828
Article：Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2
Periodicals：Molecular Cancer
IF：15.302
Article：Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells
Periodicals：Molecular Therapy: Nucleic Acids
IF：8.889
Article：miR-1301 inhibits hepatocellular carcinoma cell migration, invasion, and angiogenesis by decreasing Wnt/β-catenin signaling through targeting BCL9
Periodicals：Cell Death and Disease
IF：8.469
Article：Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2
Periodicals：Molecular Cancer
IF：7.776
Article：TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway
Periodicals：Journal of Hematology & Oncology
IF：7.333
Article：p53 dynamics orchestrates with binding affinity to target genes for cell fate decision
Periodicals：Cell Death & Disease
IF：6.304
Article：MicroRNA-936 induces cell cycle arrest and inhibits glioma cell proliferation by targeting CKS1
Periodicals：Am J Cancer Res
IF：6.166
Article：MicroRNA-1301 inhibits proliferation of human glioma cells by directly targeting N-Ras
Periodicals：Am J Cancer Res
IF：6.166
Article：MicroRNA-520d-5p inhibits human glioma cell proliferation and induces cell cycle arrest by directly targeting PTTG1
Periodicals：Am J Cancer Res
IF：6.166
Article：MicroRNA-1468-5p inhibits glioma cell proliferation and induces cell cycle arrest by targeting RRM1
Periodicals：Am J Cancer Res
IF：6.166
Article：MicroRNA-625 inhibits the proliferation and increases the chemosensitivity of glioma by directly targeting AKT2
Periodicals：Am J Cancer Res
IF：6.166
Article：p53 dynamics orchestrates with binding affinity to target genes for cell fate decision
Periodicals：Cell Death & Disease
IF：5.638
Article：lncRNAL20992 Regulates Apoptotic Proteins to Promote Lead-Induced Neuronal Apoptosis
Periodicals：Toxicological Sciences
IF：4.181
Article：Long noncoding RNA SFTA1P promoted apoptosis and increased cisplatin chemosensitivity via regulating the hnRNP-U-GADD45A axis in lung squamous cell carcinoma
Periodicals：Oncotarget
IF：3.765
Article：OCT4B1 Regulates the Cellular Stress Response of Human Dental Pulp Cells with Inflammation
Periodicals：BioMed Research International
IF：3.411
Article：Systematic identification and characterization of long non-coding RNAs in mouse mature sperm
Periodicals：PLOS ONE
IF：2.766
Article：Calcitonin gene?related peptide induces IL?6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893
Periodicals：Molecular Medicine Reports
IF：2.085
Article：Calcitonin gene?related peptide induces IL?6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893
Periodicals：Molecular Medicine Reports
IF：1.922
Article：Silencing nc886, a Non-Coding RNA, Induces Apoptosis of Human Endometrial Cancer Cells-1A In Vitro
Periodicals：Medical Science Monitor
IF：1.894
【2016年】
Article：miR-3188 regulates nasopharyngeal carcinoma proliferation and chemosensitivity through a FOXO1-modulated positive feedback loop with mTOR–p-PI3K/AKT-c-JUN
Periodicals：NATURE COMMUNICATIONS
IF：14.92
Article：A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis
Periodicals：Archives of Toxicology
IF：5.728
Article：Infection of Common Marmosets with GB Virus B Chimeric Virus Encoding the Major Nonstructural Proteins NS2 to NS4A of Hepatitis C Virus
Periodicals：Journal of Virology
IF：5.103
Article：Let-7f Regulates the Hypoxic Response in Cerebral Ischemia by Targeting NDRG3
Periodicals：Neurochemical Research
IF：2.772
【2013年】
Article：An EAV-HP Insertion in 59 Flanking Region of SLCO1B3 Causes Blue Eggshell in the Chicken
Periodicals：PLOS Genetics
IF：5.540
