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環狀RNA（Circular RNAs）是廣泛且多樣地存在于多種生物細胞中，具有調控基因表達作用的一類內源性ncRNA分子。目前的研究中，僅僅明確了circRNA具有吸附miRNA的海綿作用、調控基因轉錄等作用。但是想要進一步明確circRNA在生物體內的形成機制及發揮的功能仍需要更多的circRNA相關數據來佐證。因此，circRNA過表達載體在針對circRNA功能機制的研究中起到必不可少的工具性作用。

      伯信生物利用專利技術，成功研發出特異性準確過表達circRNAs的表達載體，率先為研究者提供簡便高效的circRNAs 過表達研究策略。現已推出2種circRNAs表達載體，適用于普通真核表達，慢病毒包裝，綠色熒光和嘌呤霉素篩選等多種用途。該載體含有伯信生物專利技術的circRNAs環化表達框架，載體轉染細胞后可通過RNA剪接形成circRNAs分子。研究者僅需以PCR擴增目標circRNAs的線性序列，克隆進表達載體中即可，大大簡化實驗步驟，節約時間。

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                    *升級版circRNA過表達載體（質粒、慢病毒），過表達效率高達1000倍以上！環化效率高達95%！
1）過表達效率高——circRNAs 表達載體上加有伯信生物專利技術的上下游環化框架，驗證過的所有 circRNAs 都能顯著過表達；

2）序列環化準確——環化框架內部引入伯信生物專利技術的環化介導序列，能有效保證目標 circRNAs 的線性序列準確環化，驗證過的所有 circRNAs 都能準確環化，無堿基添加或缺失現象；
3）過表達穩定性高——驗證過的目標 circRNAs 從 200bp 到 2500bp 序列都能實現準確高效過表達；
4）適用范圍廣——適用于普通真核表達，慢病毒包裝，綠色熒光和嘌呤霉素篩選等多種用途。

文章案例

【2025年】

Article：Cuticle protein mediates the evolution of stress resistance by generating a decoy circular RNA in spider mite.

Periodicals：Science Advances

IF：12.500

Article：o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis. 

Periodicals：Journal of Experimental & Clinincal Cancer Research: CR

IF：11.400

Article：MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis.

Periodicals：Translational Oncology

IF：4.500

【2024年】

Article：EIF4A3 modulated circ_000999 promotes epithelial-mesenchymal transition in cadmium-induced malignant transformation through the miR-205-5p/ZEB1 axis.

Periodicals：Environment International

IF：10.300

Article： Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis. 

Periodicals：Gene

IF：2.600

【2023年】

Article：N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.

Periodicals：Translational Neurodegeneration

IF：12.600

Article：Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis

Periodicals：Cancer Cell International

IF：5.800

【2021年】

Article：Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Periodicals：Cell Death & Disease

IF：8.469

Article：Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis

Periodicals：Cell Biology and Toxicology

IF：6.69

Article：CircRNA_0044556 diminishes the sensitivity of triple?negative breast cancer cells to adriamycin by sponging miR?145 and regulating NRAS

Periodicals：Molecular Medicine REPORTS

IF：2.95

Article：CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis

Periodicals：Cancer Management and Research

IF：2.886

Article：Circular RNA CircCDYL Regulates Proliferation and Apoptosis in Non-Small Cell Lung Cancer Cells by Sponging miR-185-5p and Upregulating TNRC6A

Periodicals：Cancer Management and Research

IF：2.886

【2020年】

Article：CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc

Periodicals：Molecular Cancer

IF：15.302

Article：Circ_2858 helps blood-brain barrier disruption by increasing VEGFA via sponging miR-93-5p during Escherichia coli meningitis

Periodicals：Molecular Therapy: Nucleic Acid

IF：7.032

Article：Super-Enhancer LncRNA LINC00162 Promotes Progression of Bladder Cancer

Periodicals：iScience

IF：4.447

Article：Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2

Periodicals：Cancer Management and Research

IF：2.886

Article：Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling

Periodicals：Cancer Management and Research

IF：2.886

【2019年】

Article：CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene

Periodicals：Annals of the Rheumatic Diseases

IF：14.299

Article：CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition

Periodicals：OncoTargets and Therapy

IF：3.337

Article：CircLMTK2 acts as a novel tumor suppressor in gastric cancer

Periodicals：Bioscience Reports

IF：2.942

【2018年】

Article：Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family

Periodicals：Advanced Science

IF：17.521

Article：Circular RNA transcriptomics analysis of primary human brain microvascular endothelial cells infected with meningitic Escherichia coli

Periodicals：Molecular Therapy: Nucleic Acid

IF：7.032

【2017年】

Article：TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

Periodicals：Journal of Hematology & Oncology

IF：17.388