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實驗原理：

針對目標區域設計生物素標記的特異性DNA探針偶聯磁珠，并與細胞核提取物孵育。蛋白分子與DNA探針特異性結合，通過洗脫，得到目的DNA探針-蛋白質復合物。最后采用Western Blot或質譜鑒定蛋白質類型。

 

產品優勢：

1.自主品牌：擁有自主知識產權專利。

2.快速省時：從標記探針到結果分析，所費時間顯著減少。

3.穩定可靠：DNA末端標記生物素，不影響蛋白結合位點。標記好的DNA可以保存一年。

4.配備完整：只需要自備生物素末端標記的DNA探針及核蛋白質樣品。

5.可得到完整、高濃度蛋白，用于質譜檢測。

技術流程：

結果實例：

詳見產品說明書：Bes5004 DNA pulldown

文章案例

Article：Targeting chaperone-mediated autophagy to regulate osteoclast activity as a therapeutic strategy for osteoporosis. 

Periodicals：Materials today. Bio

IF：10.200

Article：BaeR and H-NS control CRISPR-Cas-mediated immunity and virulence in Acinetobacter baumannii. 

Periodicals：mSystems

IF：4.600

Article：Short-term starvation inhibits CD36 N-glycosylation and downregulates USP7 UFMylation to alleviate RBPJ-maintained T cell exhaustion in liver cancer.

Periodicals：Theranostics

IF：13.300

Article：KRASG12D-driven pentose phosphate pathway remodeling imparts a targetable vulnerability synergizing with MRTX1133 for durable remissions in PDAC.

Periodicals：Cell reports. Medicine

IF：11.700

Article：The SOX18-OTUB1-YAP1 axis: a new endometriosis target. 

Periodicals：Journal of Translational Medicine

IF：7.500

Article：HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification.

Periodicals：Biology Direct

IF：5.700

Article：Identification of a distal enhancer of Ucp1 essential for thermogenesis and mitochondrial function in brown fat.

Periodicals：Communications Biology

IF：5.200

Article：HIF-3α/PPAR-γ Regulates Hypoxia Tolerance by Altering Glycolysis and Lipid Synthesis in Blunt Snout Bream (Megalobrama amblycephala). 

Periodicals：International Journal of Molecular Sciences

IF：4.900

Article：A distal enhancer of Pparα regulates thermogenesis and mitochondrial function in brown fat. 

Periodicals：PLoS genetics

IF：3.700

Article：DDR1 promotes metastasis of cervical cancer and downstream phosphorylation signal via binding GRB2.

Periodicals：Cell death & disease

IF：8.100

Article：Oncostatin M/Oncostatin M Receptor Signal Induces Radiation-Induced Heart Fibrosis by Regulating SMAD4 in Fibroblast. 

Periodicals：International journal of radiation oncology, biology, physics

IF：6.400

Article： USP15, activated by TFAP4 transcriptionally, stabilizes SHC1 via deubiquitination and deteriorates renal cell carcinoma. 

Periodicals：Cancer science

IF：4.500

Article：GDF15 enhances anoikis resistance and metastasis of gastric cancer through protective autophagy. 

Periodicals：Cellular signalling

IF：4.400

Article：KIS, a target of SOX4, regulates the ID1-mediated enhancement of β-catenin to facilitate lung adenocarcinoma cell proliferation and metastasis.

Periodicals：Journal of Cancer Research and Clinical oncology

IF：2.700

Article：DNA G-Quadruplex in NRP1 Promoter Facilitates SARS-CoV-2 Infection. 

Periodicals：International Journal of Molecular Sciences

IF：4.900

Article：An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long-range loop formation.

Periodicals：Cell proliferation

IF：5.900

Article：Structural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing.

Periodicals：Nature conmunications

IF：14.700

Article：TCF7L2 promotes anoikis resistance and metastasis of gastric cancer by transcriptionally activating PLAUR

Periodicals：International Journal of Biological Sciences

IF：9.200

Article：GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to Inhibit Hepatic Stellate Cell Activation

Periodicals：Cellular and Molecular Gastroenterology and Hepatology

IF：7.200

Article：Insight into mechanisms of pig lncRNA FUT3-AS1 regulating E. coli F18-bacterial diarrhea

Periodicals：PLOS PATHOGENS

IF：6.700

Article：Spo0A can efficiently enhance the expression of the alkaline protease gene aprE in Bacillus licheniformis by specifically binding to its regulatory region

Periodicals：International Journal of Biological Macromolecules

IF：8.200

Article：VviWRKY40, a WRKY Transcription Factor, Regulates Glycosylated Monoterpenoid Production by VviGT14 in Grape Berry

Periodicals：Genes (Basel)

IF：3.500

Article：An R1R2R3 MYB Transcription Factor, MnMYB3R1, Regulates the Polyphenol Oxidase Gene in Mulberry (Morus notabilis)

Periodicals：International Journal of Molecular Sciences

IF：5.600